背景：本研究旨在评估胰腺癌术后体重减轻对其长期生存质量的影响。

方法：共纳入了93例在2005年4月～2011年12月期间因原发性胰腺癌进行胰腺切除的患者。对患者特点、术前体重指数以及术后体重变化进行了回顾性评价，并分析了其与长期生存质量的关联。

结果：生存率与术前体质指数没有明显关联。术后2个月体重降低了8.4%，术后4个月降低了9.0%。严重的术后体重减轻，无论是术后2个月（P=0.033）还是4个月（P=0.014）与预后差明显相关，尤其在处于IA～IIA期胰腺癌的患者中（n=43）（2个月，P=0.005；4个月，P＜0.001）。此外，虽然在处于IIB～III期胰腺癌患者（n=50）中，严重体重减轻与其生存期缩短趋向于相关，但差异无显著性。多因素分析结果表明：术后体重减轻是评估预后的独立因素。

结论：本研究结果表明出现严重体重减轻的胰腺癌患者预后较差。

JPEN J Parenter Enteral Nutr. 2015;39(5):598-603.

Impact of Postoperative Weight Loss on Survival After Resection for Pancreatic Cancer.

Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H.

Kumamoto University Graduate School of Medical Sciences, Japan.

Saiseikai Kumamoto Hospital, Japan.

Kumamoto Regional Medical Center, Japan.

BACKGROUND: The aim of this study was to assess the effects of postoperative body weight loss on long-term survival after resection for pancreatic cancer.

METHODS: A total of 93 patients with primary pancreatic cancer underwent pancreatic resection between April 2005 and December 2011. Patient characteristics, preoperative body mass index, and changes in postoperative body weight were evaluated retrospectively and correlated with long-term survival.

RESULTS: There was no significant association between survival and preoperative body mass index. Body weight fell by 8.4% at 2 months after surgery and by 9.0% at 4 months after surgery. Severe postoperative body weight losses, both at 2 months (P = .033) and 4 months (P = .014) after surgery, were significantly associated with poor prognosis, especially among patients with stage IA-IIA pancreatic cancer (n = 43) (P = .005 at 2 months and P < .001 at 4 months). Additionally, severe body weight loss tended to be associated with shorter survival among patients with stage IIB-III pancreatic cancer (n = 50), although the difference was not significant. Multivariate analysis revealed that postoperative body weight loss was an independent prognostic factor.

CONCLUSIONS: The results of this study demonstrated that pancreatic cancer patients with severe postoperative body weight loss have poorer postoperative outcomes.

KEYWORDS: body weight; operation; pancreatic cancer; prognosis

PMID: 24486859

DOI: 10.1177/0148607114520992